Alcohol ingestion reduced acetylcholine-binding protein in the submandibular gland of the rat
정보현, 유기연,
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정보현 ( Jung Bo-Hyun ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
유기연 ( Yoo Ki-Yeon ) - Gangneung-Wonju National University College of Dentistry Department of Anatomy
Abstract
Continuous alcohol ingestion may lead to various dental diseases because a hyposalivation. In this study, we investigated changes in pathology and choline acetyltransferase (ChAT, an enzyme for synthesis of acetylcholine) in the brain and acetylcholine-binding protein (AchBP, a protein responsible for modulation of synaptic transmission in cholinergic synapses) in the submandibular gland after alcohol ingestion. There was no change in neuronal death and expression of ChAT in superior salivary nucleus after alcohol ingestion. In the submandibular gland, expression of AchBP were significantly reduced after alcohol ingestion. Therefore, decrease of saliva secretion by alcohol ingestion is less related to damage of neurons in the superior salivary nucleus and decrease of acetylcholine synthesis or cholinergic neurotransmission.
키워드
Alcohol; Hyposalivation; Salivary neurotransmission; Submandibular gland
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